| Pick | Rd | Team | Player | Pos | School | Age | G |
|---|---|---|---|---|---|---|---|
| 1 | 1 | BUF | O.J. Simpson ★ | RB | Southern California | 22 | |
| 2 | 1 |
ATL
Atlanta Falcons |
George Kunz | T | Notre Dame | 22 | |
| 3 | 1 |
PHI
Philadelphia Eagles |
Leroy Keyes | DB | Purdue | 22 | |
| 4 | 1 |
PIT
Pittsburgh Steelers |
Joe Greene ★ | DT | North Texas | 22 | |
| 5 | 1 | CIN | Greg Cook | QB | Cincinnati | 22 | |
| 6 | 1 |
BOS
Boston Patriots |
Ron Sellers | WR | Florida State | 22 | |
| 7 | 1 |
SFO
San Francisco 49ers |
Ted Kwalick | TE | Penn State | 22 | |
| 8 | 1 |
RAM
Los Angeles Rams |
Larry Smith | RB | Florida | 22 | |
| 9 | 1 | SDG | Marty Domres | QB | Columbia | 22 | |
| 10 | 1 |
RAM
Los Angeles Rams |
Jim Seymour | WR | Notre Dame | 22 | |
| 11 | 1 |
MIA
Miami Dolphins |
Bill Stanfill | DE | Georgia | 22 | |
| 12 | 1 |
GNB
Green Bay Packers |
Rich Moore | DT | Villanova | 22 | |
| 13 | 1 |
NYG
New York Giants |
Fred Dryer | DE | San Diego State | 23 | |
| 14 | 1 |
CHI
Chicago Bears |
Rufus Mayes | T | Ohio State | 21 | |
| 15 | 1 | HOU | Ron Pritchard | LB | Arizona State | 22 | |
| 16 | 1 |
SFO
San Francisco 49ers |
Gene Washington | WR | Stanford | 22 | |
| 17 | 1 |
NOR
New Orleans Saints |
John Shinners | G | Xavier | 22 | |
| 18 | 1 | SDG | Bob Babich | LB | Miami (Ohio) | 22 | |
| 19 | 1 |
STL
St. Louis Cardinals |
Roger Wehrli ★ | DB | Missouri | 21 | |
| 20 | 1 |
CLE
Cleveland Browns |
Ron Johnson | RB | Michigan | 21 | |
| 21 | 1 |
RAM
Los Angeles Rams |
Bob Klein | TE | Southern California | 22 | |
| 22 | 1 | OAK | Art Thoms | DT | Syracuse | 22 | |
| 23 | 1 | KAN | Jim Marsalis | DB | Tennessee State | 23 | |
| 24 | 1 |
DAL
Dallas Cowboys |
Calvin Hill | RB | Yale | 22 | |
| 25 | 1 | BAL | Eddie Hinton | WR | Oklahoma | 22 | |
| 26 | 1 | NYJ | Dave Foley | T | Ohio State | 21 |
★ = Pro Football Hall of Fame